In particular, in computers utilizing a memory management unit (MMU) to translate memory addresses, the virtual and physical addresses refer to an address before and after translation performed by the MMU, respectively.
For example, a 16-bit computer with a 16-bit memory data bus, such as Intel 8086, generally has less overhead if the access is aligned to an even address.
[2][3] If the 16-bit data value starts at an odd address, the processor may need to perform two memory read cycles to load the value into it, i.e. one for the low address (throwing away half of it) and then a second read cycle to load the high address (throwing away again half of the retrieved data).
On some processors, such as the Motorola 68000 and Motorola 68010 processors, and SPARC processors, unaligned memory accesses will result in an exception being raised (usually resulting in a software exception, such as POSIX's SIGBUS, being raised).
[2] The direct memory access (DMA) feature allows other devices in the mother board besides the CPU to address the main memory.