First Andreas Osiander and then the Italian ex-priest Francesco Stancaro, two Calvinist professors at the University of Königsberg, preached in Pińczów.
Stancaro moved Olesnicki to drive out the monks and convert the monastic church at Pinczow to Calvinist rite November 25, 1550.
A plan was started in 1578 to reopen as a university, but the acquisition of the town by the Bishop of Kraków led to the end of Calvinist activity.
From 1558-1562 Daniel z Łęczycy operated a printing press at Pińczów publishing Andrzej Frycz Modrzewski and others.
After printing an antitrinitarian work by Stancaro it was burned on 1 September 1559 but restarted and ran for another 3 years.