The Pian Upe Wildlife Reserve is a conservation area in the Karamoja subregion of northeastern Uganda.

[2] A government-led project to convert land just south of the Greek River for agriculture threatened the viability of wildlife conservation in the whole area.

[1] A 2003 proposal to degazette the reserve in order to farm fruit on the land was blocked.

[1] Although the area once supported healthy populations of lions, elephants, black rhinos and giraffes, these are now locally extinct.

In October 2019 15 giraffes from Murchison Falls National Park where reintroduced in the reserve by UWA.

Others known to inhabit the area (as of 1996) include:[1] Pian Upe is home to enormous rock pythons and smaller but venomous puff adders.