Picayune (/pɪkəˈjuːn/ pik-ə-YOON) is the largest city in Pearl River County, Mississippi, United States.

Picayune was incorporated in 1904, and was named by Eliza Jane Poitevent Nicholson in late 1883 or early 1884.

[3] The local post office contained a mural, subsequently covered over, Lumber Region of Mississippi, painted by Donald H. Robertson in 1940.

[5] While Picayune received extensive damage from Hurricane Katrina, it was not as severe as in other nearby cities.

[6] The bulk of the Katrina damage in Picayune was caused by high winds, as the eye wall passed over the city.

The wind also caused hundreds, if not thousands, of downed trees and power outages of up to a few weeks.

[14] Television and radio stations that are part of the New Orleans and Gulfport–Biloxi listening areas serve the city.

The United States Postal Service operates the Picayune Post Office.

[15] Amtrak's Crescent train connects Picayune with the cities of New York, Philadelphia, Baltimore, Washington, Charlotte, Atlanta, Birmingham, and New Orleans.

Mississippi Highway 43 is the main connection to and from the east, connecting to Interstate 10 near Kiln, MS. Picayune Municipal Airport has a 5,000 ft (1,500 m) runway and is a popular destination for private fixed-wing and rotary aircraft visiting the New Orleans area.