She was the daughter of Edoardo Bueri, a member of a family of ancient lineage from Florence with economic interests in other cities; the family was in fact in Verona in the first half of the fourteenth century when she was born.

[citation needed] She was married to the young banker Giovanni di Bicci de' Medici in 1386.

[3] Upon her death, Carlo Marsuppini wrote a eulogy in which he sang her praises, in which he compared the love between Piccarda and Giovanni with that of famous couples from antiquity.

[3][4] In it, he compared her with Penelope, Artemisia II of Caria, Julia and Porcia.

By her marriage, she had at least five children: Bueri is portrayed by Frances Barber in the 2016 television series Medici: Masters of Florence.