Pico Boulevard is a major Los Angeles street that runs from the Pacific Ocean at Appian Way in Santa Monica to Central Avenue in downtown Los Angeles, California, United States.

It is named after Pío Pico, the last Mexican governor of Alta California.

Major landmarks include Santa Monica College, Santa Monica High School, the Westside Pavilion mall, Fox Studios, the Hillcrest Country Club, the Crypto.com Arena, and the Los Angeles Convention Center.

The neighborhoods of Los Angeles through which Pico Boulevard travels are among the most culturally diverse in the city.

From west to east, they include the Japanese and Persian neighborhoods of Sawtelle, the 11 neighborhoods in the West Los Angeles region which are the predominantly Anglo neighborhoods of Cheviot Hills and Rancho Park, the business and entertainment center of Century City, and the primarily and largely Jewish, African American and Latino neighborhoods of South Robertson, Crestview, South Carthay, Carthay Square, Little Ethiopia, Wilshire Vista and Picfair Village, the Latino Mid-Wilshire subregion, the heavily Korean neighborhoods of Country Club Park and Koreatown, the predominantly Central American neighborhoods of the Byzantine-Latino Quarter and Pico Union, the redeveloping South Park, the Garment District of Downtown Los Angeles and the Mexican-American neighborhood of Boyle Heights.