Founded in 1897, Piedmont's Demorest campus includes 300 acres in a traditional residential-college setting located in the foothills of the northeast Georgia Blue Ridge Mountains.

The college also opened a campus in Athens, Georgia, and began offering off-campus graduate education courses across the state.

In 2019, Piedmont College then president James Mellichamp was accused of sexual harassment by tenured professor Rick Austin, who was also the mayor of Demorest.

[15] However, the Equal Employment Opportunity Commission was unable to conclude that Austin's accusations stated any claim for violating law.

[16] Piedmont College sued the City of Demorest, demanding that Austin forfeit his tenured position and resign as mayor.

The college argued that the mayor and city council of Demorest violated its constitutional rights under the Equal Protection Clause of the 14th Amendment of the U.S. Constitution when the city instituted a rate hike in water and sewage fees targeted solely at the college beginning in 2019.

The Johnny Mize Athletic Center houses the O’Neal Cave Arena for basketball and volleyball.

The installation of the bridge was a joint project of the Georgia Department of Transportation, Piedmont College and the city of Demorest.

[27] The lake was drained due to an irreparable dam, and the property was turned into a wetlands for students and faculty to use in their studies.

The 58,000 square foot commons features the campus dining hall, fitness center (complete with a full-size basketball court with a walking track, a rock-climbing wall and a racquetball court), the official Piedmont College bookstore and a Starbucks cafe.

The college opened a small outreach facility[28] in 1996 and now occupies seven buildings near the heart of downtown Athens on Prince Avenue.

For graduate students, there are programs in business (MBA), nursing (BSN), and education (MA, MAT, EDS, and EdD).

The School of Business is located in Rogers Hall, and there is a large recreation center for intramural and fitness activities.

Lane Hall on North Milledge Avenue[30] houses the library and facilities for the School of Nursing and Health Sciences.

The BA program includes concentrations in accounting, finance, general business, management, and marketing.

[38][39] The R.H. Daniel College of Nursing & Health Sciences offers the BSN degree for students preparing for initial licensure.

[41] Piedmont University has over 50 student clubs and organizations and 19 intercollegiate sports teams competing in NCAA Division III.

[34] In addition to clubs and service organizations, Piedmont offers creative outlets for singers, musicians, and actors.

The Piedmont Singers is a 50-member ensemble of selected students that performs on campus and each year tours in the U.S. or abroad.

Under the guidance of advisor Joseph Dennis, The Roar Magazine is expected to remain at Piedmont University for the foreseeable future.

The name is a reference to the Mayflower ship of the Pilgrims, honoring Piedmont's relationship to American Congregationalism.

[44] Piedmont College teams participate as a member of the National Collegiate Athletic Association's Division III.

Piedmont was a charter member of the Great South Athletic Conference (GSAC) until the 2012–13 school year.