His poetry is characterized by lyricism and a pessimistic view of the relationship between man and society, with characters often marked by loneliness and a certain contrast between passion and rationality.
Often this contrast is symbolically sought from San Secondo in the confrontation between the Italian North, characterized by a rational life, concrete and gray, and the Italian South characterized as a mythical dream, passionate colors of life.
Among his most important plays are La sirena ricanta, which debuted in 1908, and Marionette, che passione!
According to Gaetano Savatteri, the true significance of Rosso di San Secondo was overshadowed by the figure of Pirandello.
Following the great success of Marionette, che passione!, Rosso di San Secondo wrote several other plays, including La bella addormentata in 1919, L'ospite desiderato in 1921, Tra vestiti che ballano in 1927, Il ratto di Proserpina del 1954, Una cosa di carne, Il delirio dell'oste Bassà, Amara.