Together with Cardinal Alderano Cibo, he founded an institute for runaway children.

On 20 April 1681 he was consecrated bishop by Alderano Cibo, Cardinal-Bishop of Frascati in Jesi.

His works on mysticism and spirituality were criticized by the Jesuit Paolo Segneri.

In 1688, the Inquisition banned his Quietistic writings about the passive resignation of the soul to God for being heretically mystical.

Oddly enough, a treatise for women authored by the cardinal was still translated for English Protestants.