His breakthrough role came with the critically acclaimed film El Alamein: The Line of Fire, which earned him widespread praise in Italy.

Favino's American credits includes Night at the Museum (2006), The Chronicles of Narnia: Prince Caspian (2008), Angels & Demons (2009), World War Z (2013) and Rush (2013).

[1] He has appeared in more than 40 European films and television series since the early 1990s, including Paolo Poeti's Amico mio, Gabriele Muccino's The Last Kiss, Gianni Amelio's The Keys to the House, Giuseppe Tornatore's The Unknown Woman and Ferzan Özpetek's Saturn in Opposition.

In 2006 he received the David di Donatello award – the Italian equivalent of the Oscar – for his role in the crime film Romanzo Criminale, directed by Michele Placido.

[4] Other significant roles include the partisan leader Peppi Grotta in Spike Lee's Miracle at St. Anna in 2008, the sadistic riot control force policeman Cobra in Stefano Sollima's ACAB – All Cops Are Bastards in 2012, the anarchist Giuseppe Pinelli in Marco Tullio Giordana's Piazza Fontana, and the W.H.O.