In 1998 he worked with Daniele Luchetti in I Piccoli Maestri, which competed for the Golden Lion at the Venice International Film Festival.

In the same year he won three prizes for his role in Radiofreccia, directed by rock star Luciano Ligabue, including David di Donatello for Best Actor.

This film was a big success in Italy and in Turkey, and Accorsi, who played the role of a homosexual man, won three awards for his interpretation.

He also starred in David Blair's Tabloid TV (UK) and in Marco Ponti's Santa Maradona.

Accorsi worked with Diane Kruger in Les Brigades du Tigre (2005) and with Julie Depardieu in La Faute à Fidel.