Pierluigi Orlandini (born 9 October 1972) is an Italian former footballer who played as a midfielder.

In 2000, he played 2 games for AC Milan and scored 1 goal.

He went on to spend the remainder of his career with Brescia, his former club Atalanta and Brindisi before retiring.

At international level, Orlandini also won 10 caps for the Italian under-21 team between 1992 and 1994, scoring once.

This biographical article related to association football in Italy, about a midfielder born in the 1970s, is a stub.