[2] Piero Pioppo was ordained a priest on 28 June 1985 for the diocese of Acqui[1][2] First named vicar of a parish at Carcare, he was sent to Rome to continue his studies.

He joined the diplomatic service of the Holy See on 1 July 1993 and then filled assignments in South Korea and Chile, and then in Rome in the General Affairs Section of the Secretariat of State.

[3] On 25 January 2010, Piero Pioppo was named apostolic nuncio to Cameroon and Equatorial Guinea and titular archbishop of Torcello.

[2] On 8 September 2017, Pope Francis appointed him apostolic nunciature to Indonesia[6] and on 19 March 2018 also the role of nuncio to the Association of Southeast Asian Nations (ASEAN).

[7][b] He led the delegation of the Holy See to the October 2018 conference in Bali "Our Ocean, Our Legacy",[9][10] Pioppo then organized Pope Francis' meeting with Indonesian Maritime Affairs and Fisheries Minister Susi Pudjiastuti in December at which Francis endorsed her aggressive program to restrict illegal fishing.