His group was also one of the first to demonstrate, biochemically and electron-microscopically, that the nucleosome is the smallest unit of chromatin (Cell, Vol.
The core of Pierre Chambon's scientific work has been dedicated to the genetics and molecular biology of vertebrates.
Cloning of estrogen and progesterone receptors; elucidation of the mechanism of action of steroid hormones at the level of gene expression (1985-1990) 8.
Discovery of the nuclear receptor superfamily, their three-dimensional structure, molecular mechanism of action, and their physiological and pathophysiological functions at the cellular and organismal levels (1987-) 10.
Discovery of a method allowing somatic mutations to be induced in mice at a chosen time and in a specific tissue or cell type.