His entire family had just emigrated back to France when they were all engaged to follow Cavalier de La Salle in his attempt to colonize Louisiana (1684).
Shortly after landing there, Talon was sent to learn the language of the Cenis Indians, and spent six years in their country about one hundred leagues inland at the limit of La Salle's discoveries.
Talon, in his evidence sworn at Brest (1698), gives abundant details regarding the character, customs, and religious rites of the Indian tribes with whom he had lived, as well as of the fauna and flora of the southern portion of the continent.
The tribes he mentions are inscribed under the following names: Clamcoets, Temerlouans, Tohos, Cenis, Ayennys, Amalchams, Canotinos, Paouitas, and Chomans.
There is a great probability, although Talon cannot affirm it as certain, that one of the rivers seen by him during his intercourse with the Indians was the Mississippi, which La Salle's premature death prevented the discoverer from seeing again.