Piero de Bonzi (also Pierre; 15 April 1631 - 11 July 1703) was an Italian-French Roman Catholic cardinal.

He was also grand-nephew of Cardinal Jean de Bonsi.

He was educated by his uncle Clément Bonzi, bishop of Béziers, who made him join the ecclesiastical state and he became Resident of Ferdinando II de' Medici, Grand Duke of Tuscany in the French court.

In 1672 Bonzi was created cardinal priest by Pope Clement X, and transferred to the metropolitan see of Narbonne two years later.

From about 1693, he suffered from epilepsy and because of poor health did not participate in the Papal conclave of 1700.