Pierreclos (French pronunciation: [pjɛʁklo]) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.

The name Pierreclos come from "Petra Clausa" meaning Closed stone, or tomb, in Latin.

Before the French Revolution, the history of the village was closely linked to its castle.

Pierreclos is surrounded by vineyards which are used for great quality wines.

The main employer is a low-cost salted meat producer.