He was born in Florence on 15 March 1455, the son of the famous jurist Benedetto Accolti the Elder and his wife Laura Federighi.
[7] During the 1521–1522 papal conclave that followed the death of Leo, Cardinal Accolti was one of the Papabile who opposed the Emperor, receiving five votes on the first ballot.
This prompted a satire on the part of Pietro Aretino, whose patron, Cardinal Giulio de' Medici, was also a contender.
French chancellor Antoine Duprat, considered Accolti the most cultured and literate member of the college of cardinals.
[2] Accolti died on 11 December 1532 in Rome and was buried in the church of Santa Maria del Popolo, without an inscription.