Sometimes referred to as Pietro da Venezia, he was the son of Giuseppe Giovanni Battista Guarneri, filius Andreae, and the last of the Guarneri house of violin-makers Guarnieri lived in Cremona with his father until 1717.
Finding life in Casa Guarnieri in some way uncongenial, he left Cremona for good in 1717.
Here he blended the Cremonese techniques of his father with Venetian, working with Comel, Gobbetti and Tononi.
The Venetian makers of the same period were Matteo Goffriller, Carlo Annibale Tononi, Francesco Gobbetti, Domenico Montagnana and Sanctus Seraphin.
He married Angiola Maria Ferrari on 5 April 1728, with whom he had eleven children.