Lakshmi was born in Madhapatnam, Samalkota Mandal, East Godavari district.
She married Pilli Veera Venkata Sathyanarayana Murthy, alias Sathibabu.
[citation needed] Lakshmi began her political career with Telugu Desam Party in 1999.
Contesting again on Telugu Desam Party ticket, she won the 2014 Andhra Pradesh Legislative Assembly Election defeating Chelluboyina Srinivasa Venugopala Krishna of YSR Congress Party by a margin of 9,048 votes.
[5][6] She contested again on TDP ticket but lost the 2019 Andhra Pradesh Legislative Assembly Election to Kurasala Kannababu of YSRCP by a margin of 8,789 votes.