Pilosocereus millspaughii, commonly called the Key Largo tree cactus,[citation needed] is a species of flowering plant in the family Cactaceae, native to Florida, The Bahamas, Cuba, Haiti, and the Turks and Caicos Islands.

[1] It was first described by Nathaniel Lord Britton in 1909 as Cephalocereus millspaughii.

[2] It is now locally extinct in Florida due to sea level rise.

[3] It is a shrubby to arborescent, branched succulent which can reach heights of up to 7 m (23 ft).

[4] The fragrant, cream-coloured flowers smell like garlic.