Earl Hickey (Jason Lee), a thief, narrates the last few years of his life, explaining that he married a six-month pregnant woman named Joy (Jaime Pressly) while drunk in 1999.
After leaving the hospital, Earl and Randy move into a motel where they meet a pretty Mexican maid, Catalina (Nadine Velazquez).
When Earl picks up trash to atone for item #136, "I've been a litterbug", he finds his lost lottery ticket.
He decides that karma works, and as such resolves to continue making up for items on the list, beginning with #64: "Picked on Kenny James".
Kenny's life is good, but he has nobody to share it with, so Earl decides to hire a prostitute, Patty, to have sex with him.
In response to one shouting "fags" out the window, Earl walks up to the college student, pulls him out of the car, punches him in the face, and tells him to learn about tolerance.
Kenny stops Earl, who asks for the student's name to put on his list, explaining that he must make up for his mistake.