His photographs have been exhibited at the Venice Biennale, the Museum of the Ara Pacis in Rome, and galleries in Italy, Germany, England, France and Switzerland.

In 1982 he had his first exhibition at the Venice Biennale, entitled Maschere e Persone, images depicting popular religious and pagan rituals in Southern Italy.

[1] In the 1990s he began creating books of photographs of modern architecture, always in black and white, presenting the buildings as complex works of visual art, with contrasts and harmonies of light and darkness.

His early photo books included Mario Botta seen by Pino Musi, depicting the work of the architect Mario Botta, especially Évry Cathedral, the only modernist cathedral completed in the 20th century; a photographic study of the Chapelle Notre Dame du Haut à Ronchamp, the Modernist church designed by Le Corbusier; and a book devoted on the work of the 1930s avant-garde architect Giuseppe Terragni.

[2] The book "Border Soundscapes" (2019) illustrated Musi's theme of the similar effects achieved by music and photography, through contrasts of light and dark, loudness and softness, and variations of key and harmony.

The rooms are empty of people, but the surgical couch, scattered instruments, fabrics and debris suggest the drama that took place in the same space a few minutes earlier.