It is one of the few games to use the Hold-And-Modify display mode of the Amiga for in-game graphics, a mode which allows thousands of colors to be displayed at once, but in a format that's better suited to static images than moving objects.

[citation needed] Pioneer Plague was not ported to other systems.

Williams also wrote the 1986 Amiga game Mind Walker.

[1] Pioneer Plague received an 88% from Amiga Computing and 86% from Zzap!64.

[3] British magazine Computer and Video Games was less enthusiastic with an overall score of 39%, commending the graphics but criticizing playability.