[5] Its flow begins in southeastern Saskatchewan, just south of the town of Grenfell and travels in a southeastern direction into Manitoba in the Westman Region where it empties into Oak Lake through the Oak Lake Marsh.

"The Pothole Region is the result of the last Pleistocene glaciation and it is estimated that there are between 5 and 8 million wetlands or small depressions, which have an important biological role and impact on the ecosystem.

It is estimated that the Pipestone Creek has a GDA (Gross Drainage Area) and EDA (Effective Drainage Area) of 2,242 km2 (866 sq mi) and 559 km2 (216 sq mi), respectively, and that near 11% of the watershed is covered by wetlands.

From there it winds its way past Saint Hubert Mission, an early French colony.

From Cromer, it continues in a more southerly direction until it nears Reston where it heads east towards the communities of Pipestone and Oak Lake Indian Reserve.