It was commissioned by Ottoman Grand vizier Piri Mehmed Pasha (in office 1518–1523), and built in 937 AH (1530–31) according to the wall-hung inscription above the main gate.

The mihrab, situated in a stem, which is topped by a half dome, opens to the main prayer room by a large pointed arch.

The minaret's base is original while the tower was re-built during the renovation works of the mosque complex, which were commissioned by the trustee Sâdeddin Bey and took place 1179 AH (1765–66), according to an inscription situated on both sides of the main gate..

[2] The mosque complex consisted of facilities such as guest house for travellers' stay up to three days, imaret, kitchen, dining room, woodshed, inn, infants' school, nine-room madrasa, orphanage and service building for soldiers returned from the Belgrade Fortress.

In order to continue the activities of those facilities, about ten shops were endowed to the mosque complex for in addition to cropland, mill, well and farm.

[1] The fountain in the courtyard of the mosque, which is designed in mixture of the Baroque and Neoclassical Empire style, is named after Hacı İsmail Ağa.

[2] Piri Mehmet Pasha Mosque took its recent outlook after the restoration works carried out by the Directorate General of Foundations between 1961 and 1971.