Due to the unfavourable geography of Pirmasens, the station is now only connected by a single track and non-electrified branch line.

This route, called the Biebermühl Railway, runs almost seven kilometres north to Pirmasens Nord station.

On 1 April 1947, Pirmasens station was transferred to the control of the railway division at Mainz, as the Saarland had been separated from Germany.

From 1 May 1972, until the founding of Deutsche Bahn AG in 1994, the station was under the control of the railway division in Saarbrücken.

These were in turn replaced by class 643 (Bombardier Talent) or 642 (Siemens Desiro) diesel multiple units.

From 1994 to 2002, there was also a Regional-Express service (RE 4) via Kaiserslautern to Bingen Hauptbahnhof, running via the Alsenz Valley Railway (Alsenztalbahn).

Since 2006, Regionalbahn services have been restored in the evenings, weekends and on holidays between Pirmasens and Karlsruhe.