It is a stop on the Rhine-Neckar S-Bahn and Deutsche Bahn’s Intercity-Express network and a hub for all the regional trains of the western Palatinate.

On 10 June 2007, the Rhealys high-speed rail consortium established a service with a stop in Kaiserslautern, reducing travel time to Paris to two and a half hours.

Prior to the closure of the Einsiedlerhof marshalling yard, Kaiserslautern was a significant rail freight hub.

On 16 May 1871 the Alsenz Valley Railway was completed from Bad Münster to Hochspeyer; its trains ran into Kaiserslautern.

There are the following long-distance and local transport connections: Media related to Kaiserslautern Hauptbahnhof at Wikimedia Commons