Early Pittsford served as the governmental seat for the town of Northfield, comprising most of what is now eastern Monroe County.

In 1813, after the surrounding towns were organized, reducing Northfield's territory, the name Pittsford was adopted to honor the Vermont birthplace of Colonel Caleb Hopkins, a farmer, community leader and hero from the War of 1812.

Because of its superior waterpower, Rochester soon eclipsed Pittsford as Monroe County's dominant economic and population center.

Boosted by the arrival of the Rochester & Auburn railroad in 1834, Pittsford remained an important shipping center for local grains and produce until the late twentieth century.

The present charm of the Village's waterfront is due to the survival of historic canal warehouses, mills and silos, which in recent years have been rehabilitated for offices, boutiques, and restaurants.

Pittsford Farms, the oldest of the three village estates, was established in the 1860s by Jarvis Lord, a canal contractor.

The property has retained its historic appearance and remains today a 200-acre (0.81 km2) working farm, owned by descendants of the Zornow family.

The Town of Pittsford has purchased the development rights to this farm and seven others to ensure their open space remains for generations to come.

Over the last fifty years, residents, business people, and government officials have worked cooperatively to preserve, enhance and revitalize Pittsford Village.

Today the Village of Pittsford is widely admired for the preservation of its historic character and its charming walkable business district.