The northeast portion of the Mojave National Preserve makes up the northwestern region of the Piute Valley, at a four-valley water divide point.

The Piute Valley Watershed[1] is the first watershed southeast of Las Vegas–Lake Mead to meet the Colorado River; the Piute Wash outfall with the Colorado River is in California at Needles.

U.S. 95 is the route traversing the Piute Valley north–south, connecting at the south to the east–west Interstate 40 in California and the northern foothills of the Sacramento Mountains.

West of the McCullough's lie the endorheic Roach and Ivanpah Dry Lakes of Ivanpah Valley; the valley extends north into Las Vegas' southwest, a tributary to the Las Vegas Wash. Ivanpah Valley turns southeast to meet the water divide point.

The northeast borders of the New York and smaller Castle Mountains meet the north of the Piute Range; to the west of the Piute's, east of the New York Mountains is the southerly draining endorheic Lanfair Valley.