The Piute Range is located in the Mojave Desert, primarily in northeast San Bernardino County, California, United States, with a north portion in Nevada.

West of the McCullough's lie the endorheic Roach and Ivanpah Dry Lakes of Ivanpah Valley; the valley extends north into Las Vegas' southwest, a tributary to the Las Vegas Wash. Ivanpah Valley turns southeast to meet the water divide point.

Southwest, the Piute Valley drains south, then Piute Wash turns east and descends steeply at the Dead Mountains to its outfall at the Colorado River and Needles.

The northeast preserve corner is anchored by the water divide point.

The northeast borders of the New York and smaller Castle Mountains meet the north of the Piute Range; to the west of the Piute's, east of the New York Mountains is the southerly draining endorheic Lanfair Valley.