[1] Unlike other mosques designed by Sinan that have a large central dome, the Piyale Pasha Mosque is constructed with six identical domes, arranged as two rows of three, each with a diameter of about 9 m (30 ft).

The domes are supported in the center of the prayer hall by a pair of slender granite pillars.

Around three walls of the interior are a row of Iznik tiles with inscriptions in a white thuluth script on a cobalt-blue background.

[2] The domed octagonal mausoleum to the northwest of the mosque contains the tomb of Piyale Pasha together with those of his sons and daughters.

[3] A number of identical Iznik tiled lunette panels that are now on display in the Musée du Louvre in Paris,[4][5] the Museu Calouste Gulbenkian in Lisbon[6][a] and the Victoria and Albert Museum in London[8] are believed to have been removed from the Piyale Pasha Mosque in the 19th century.