Pizhou (Chinese: 邳州; pinyin: Pīzhōu) is a county-level city under the administration of Xuzhou, Jiangsu province, China.

As of 2020 it had a population of 1,462,563;[2] it borders the Shandong prefecture-level cities of Linyi to the northeast and Zaozhuang to the northwest.

Pizhou lies to the northeast of Xuzhou City at the intersection of the Grand Canal and Longhai Railway.

To the north of Pizhou, there is the well-known Tai'erzhuang District of Zaozhuang City, Shandong Province.

Pizhou City is home to the longest Dawn redwood Metasequoia glyptostroboides avenue in the world.