Plague is a 1979 Canadian-American science fiction film about a genetic engineering accident, a fertilizing bacterium that escapes from a laboratory in Canada.

Dr. Graham is killed by the virus, while an infected but unaffected woman spreads the disease in the manner of Typhoid Mary.

Scientists Dr. Bill Fuller (Daniel Pilon) and Dr. Jessica Morgan (Kate Reid) work tirelessly to develop an antidote to stop the contagion.

The film was released on DVD in the United Kingdom from Prism Leisure Corporation as part of a 4-film collection (with Bram Stoker's Legend of the Mummy 2, Howling IV: The Original Nightmare and Night of the Living Dead) on October 7, 2002.

TV Guide found that the focus on the scientists in charge of finding the cure to be a plus, that overall the movie was laughable.