It is bordered by the Entrepotdok to the north, Plantage Muidergracht to the east and south and Nieuwe Herengracht to the west.

Due to an economic crisis caused by the Rampjaar events, the city government could not find enough buyers for the land.

In 1682, Hortus Botanicus, one of the oldest botanical gardens in the world, opened its doors across from the Wertheimpark, currently the only public park in the Centrum district of Amsterdam.

Today, Plantage still has a much greener and more spacious character compared to other neighbourhoods of the old 17th century city limits within the Singelgracht.

In the Plancius building (1876) on Plantage Kerklaan, Oefening Baart Kunst practised their performing arts.

It was this building that, on 18 July 1942, became a deportation centre from which arrested Jews were deported to extermination camps during the Nazi occupation of the Netherlands; students of the nearby University of Amsterdam evacuated Jewish babies to the countryside under the direction of Johan van Hulst.