[2] Occasionally, the nodules may lie dormant for months to years only to begin rapid and unexpected growth.

[5] Options for intervention include radiation therapy, cryosurgery, treatment with collagenase clostridium histolyticum, or surgical removal only if discomfort hinders walking.

[7] Plantar fibromatosis is most frequently present on the medial border of the sole, near the highest point of the arch.

[9] The histological and ultrastructural features of Ledderhose and Dupuytren's disease are the same, which supports the hypothesis that they have a common cause and pathogenesis.

[citation needed] A combination of physical examination of the arch and plantar fascia, as well as ultrasound imaging by a physician is the usual path to diagnosis.

[5] MRI and sonogram (diagnostic ultrasound) are effective in showing the extent of the lesion, but cannot reveal the tissue composition.

[citation needed] Recently successful treatment of Ledderhose with cryosurgery (also called cryotherapy) has been reported.

[citation needed] Cortisone injections, such as triamcinolone,[4] and clobetasol ointments[10] have been shown to stall the progression of the disease temporarily, although the results are subjective and large-scale studies far from complete.

Injections of superoxide dismutase have proven to be unsuccessful in curing the disease [10] while radiotherapy has been used successfully on early-stage Ledderhose nodules.