Plantation Island is a census-designated place (CDP) in Collier County, Florida, United States.

Plantation Island is located in southern Collier County at 25°50′47″N 81°22′6″W / 25.84639°N 81.36833°W / 25.84639; -81.36833 (25.846346, -81.368274),[5] along Halfway Creek upstream several thousand feet from Chokoloskee Bay.

It is south of Everglades City and north of Chokoloskee via State Road 29.

Plantation Island is located within the Big Cypress Area of Critical State Concern.

As of the 2020 United States census, there were 119 people, 14 households, and 0 families residing in the CDP.