The "platelet-rich fibrin matrix" (PRFM) method is a cosmetic surgery procedure involving plasma needling.
It is a way of extracting platelets from the patient's own blood and using them as a dermal filler – that is, as a substance injected under the skin of the face to try to fill out wrinkles.
[1] Nonetheless, Selphyl has been described as a "FDA approved dermal filler" in YouTube videos and trade publications.
As of March 2011[update], according to a New York Times report, it is attested by several plastic surgeons who use it but remains unproven by research.
[1] Phil Haeck, the president of the American Society of Plastic Surgeons, dismissed the procedure as "creepy", "a gimmick" and as "antiquated as bloodletting".