[7] Plautilla's father Giovanni was an artist and musician who trained her; he had a shop near the Church of Santa Maria del Popolo.
[1] She also trained with Maria Eufrasia della Croce who she later collaborated with on a painting of the Nativity for the convent at San-Giuseppe a Capo alle Case.
[1][7] Her earliest painting is a miraculous Virgin and Child made in the early 1630s, which was given to the Church of Santa Maria in Monte Santo, Rome.
[1] It is not known how she became an architect, but she may have received instruction in the orbit of Cassiano dal Pozzo who championed women artists and had an interest in architectural training.
[7] In 1644, Plautilla made two paintings: a Saint Francis and an Angel and a Floral still-life for Cardinal Francesco Barberini, the Pope's nephew.
[1] At least one source suggests that she may have had a long-term relationship with Maria-Eufradia Benedetti earlier in her life, who was a female painter of the time, but it is not made clear if it was romantic or friendly in nature.
[1] Antonio degli Effetti described his cabinet in the Studiolo di pittura nella Galleria della Ricchezza, and it also features in Giovanni Pietro Bellori's Nota delli Musei.
[4][3] In this book he claimed that Basilio designed it, but the building contract and drawings show Plautilla was the lead architect.
Sketches, paintings, and photographs of the Roman artist's work are displayed alongside published articles produced by Primarosa.