It is a crossover of the Ratchet & Clank, Jak and Daxter and Sly Cooper franchises to form a total of six main characters.

The game features six playable characters: Ratchet, Clank, Jak, Daxter, Sly Cooper, and Bentley.

It also features a total of 50 levels, which can be categorized into five "archetypes", five weapon classes, and four environments, namely Paris, France from Sly Cooper, Metropolis on Kerwan from Ratchet & Clank, Haven City from Jak and Daxter, and Planet X, which is an original environment created for the game.

Melee uses each character's iconic weapons — Sly's cane, Ratchet's wrench, and Jak's gunstaff — to hit enemies in a fashion similar to their original games.

After being abducted to this new world, Ratchet and Clank, Jak and Daxter, and Sly and Bentley are invited by their alien hosts to compete in a friendly, yet challenging competition to test their extraordinary skills and determine who the best hero duo is.

The heroes discover that all is not as it seems as Gleeber and Lunk have made the Whibbles (a race of small floating aliens) their slaves and forced them to mine their planet hollow to build what appears to be a giant weapon.

[4] On February 9, 2011, Sony released a story trailer for the game, which confirmed that all the original voice actors would return to reprise their roles.

"[6] Sony had worked with Nihilistic and several retail partners for an exclusive skin pack featuring Pirate Sly, Freedom League Jak, and Trillium Armor Ratchet.

[8] IGN gave the game a 5.0/10, commenting on the lack of a decent story along with the "boring mini-game collection with spotty controls".