The series combines classic Sesame Street sketches with new segments, where the hosts invite preschoolers to join them in games.

The show was heavily linked with Noggin's website, featuring a regular segment where computer games from the site were played.

The show encourages its young viewers to join in on the movement and learning they see onscreen, making television an active experience rather than a passive one.

Tom Ascheim, one of the show's producers and the general manager of Noggin, said "all the things kids do—running around, coloring, playing computer games—are funneled into the experience.

The background designs, many of which resemble a child's crayon drawings, are the same ones featured in Noggin's Moose and Zee interstitials.

Some of the designs (such as a lion, a dinosaur, and a bird) were featured as part of Noggin's channel logo, both in promotions for Play with Me Sesame and in general use.

Sesame Workshop lists Nickelodeon Animation Studio and its former name, Games Productions, as a "project partner" for the series.

"[14] Pam Arciero, Lisa Buckley, Tyler Bunch, Tim Lagasse, Jim Martin, Carmen Osbahr, and Matt Vogel are also credited as additional puppeteers.

[16] In Australia and Oceanic territories, the show was released on VHS and DVD by Australian Broadcasting Corporation and Roadshow Entertainment.