The series was inspired by the Umbilical Brothers' adult-oriented comedy act SpeedMouse,[5] which was also based on the idea of an imaginary remote.

"[3] In 2010, the Umbilical Brothers announced that they had completed a script for a special-length episode titled The Upside Down Movie,[6] which would act as a proper finale for the series.

[7] Nickelodeon Australia provided funding for the movie's scriptwriting,[6] but the project needed support from outside investors to start filming, which never occurred.

[8] The show's concept is based on SpeedMouse, a live comedy act that the Umbilical Brothers performed for adult audiences in the 1990s.

"[5] Producers from Sesame Workshop enjoyed the remote control in SpeedMouse and felt that the physical comedy would lend itself to a family-oriented television show.

[10] In developing the series, the creators set out to make an "adult show for kids"[3]—adapting the adult-oriented SpeedMouse for a wider audience while also adding layered jokes for parents and older viewers.

'"[5] David Collins elaborated, "The series is filled with gags that will fly over the heads of little ones and straight into the face of the parent stalking behind them.

[22] The Upside Down Show also aired on four international channels: Nick Jr. UK,[23] Nickelodeon Asia,[24] TVOKids in Canada,[25] and Boomerang in Latin America.

[30] The Umbilical Brothers also announced this on their Facebook page, writing that "there is a script in development for a movie version of The Upside Down Show.

"[31] A month later, the newspaper The Sydney Morning Herald published an interview with Shane Dundas and David Collins, in which they revealed that the project would be titled The Upside Down Movie and that it was planned to start filming within the next year.

[7] In January 2010, David Collins announced that the script had been finished, and that the project would act as a proper series finale.

[6] Collins also confirmed that Nickelodeon Australia was "hugely supportive of trying to get the film made and have been partially funding the script development.

Before the episode starts, the viewer commonly presses the wrong button and puts the brothers in a bizarre situation.

This sequence features the Action Fingers jumping over the show's title and credits, and it ends with them opening the apartment door.

The brothers' neighbor Mrs. Foil appears in the different rooms in various costumes, either helping them on their quest or unintentionally causing more trouble.

[49] Since 2018, the Umbilical Brothers have uploaded the entire series to their public YouTube channel, making every episode available to view for free.

Larisa Wiseman of Common Sense Media gave the series a 5-star review, calling it "refreshingly original; each episode is filled with clever jokes, puns, music, and tons of physical humor.

"[52] The Hollywood Reporter called the show "outrageously funny and inventive" and "imaginative to the core," saying that David and Shane "will have young viewers mesmerized.

I noticed, as I watched the show for the first time, that I was sitting cross-legged on the floor about a foot from the TV screen, absolutely entranced.

The show's opening theme won the Creative Craft Daytime Emmy Award for Main Title Design.