Plaza Centro retail stores included Almacenes Plaza, A Toda Moda, Babbages, Back Bay, Bambi, Bora Bora, Celulares Telefónica, Click's, Damasco Christian Store, La Defensa, First Bank, La Gloria, Gravity, Great Dolls & More, Group U.S.A., Humberto Vidal, JCPenney, Journeys, Joyeria Barroto, KB Toys, Kids Spot, Marianne Plus, Mastercuts, Me Salve, Now or Never, Nubes, One Price Clothing, Papillon Group, Parade of Shoes, Perfumania, Puerto Escondido, Rachel's Cards & Gift, Sophia, St. Cinnamon, Tiendas 1-2-3, Vitamin World, and Wetzel's Pretzels.

The food court would feature The Hot Potato, KFC, Sbarro, Panda Express, Burger King, El Sandwichon, Quizno's, Taco Bell, Charley's Steakery, Churro Time, and Church's.

[8] In 2008, Burlington Coat Factory would open a 37,000 square foot store at the Plaza Centro Mall, serving as an anchor and taking up space of the former Pueblo Supermarkets.

[10] On May 12, 2011, it was reported that PetSmart, the largest U.S. specialty retailer of products and services for pets, would open its fourth store in Puerto Rico in the Plaza Centro Mall with a multimillion-dollar investment.

The new PetSmart store also completed Plaza Centro's six month expansion, bringing mall occupancy to its highest level in years at the time.

During the shopping center's six month retail expansion, the following tenants had opened: Health 4 Life, Fashion Show District, DirecTV, Caguas Auto mall, restaurants such as La Casita Persa and Chicco Grill, and a renovated Clarks shoe store.

[13] On December 10, 2019, it was reported that local retailer Me Salvé was making history with the opening of its 101st store, the largest and most emblematic of the company, which had been serving the Puerto Rican people for 37 years.

Plaza Centro I is situated on a plot of land with an area of approximately 26 “cuerdas,” or 102,149 square meters, located in the Bairoa neighborhood of Caguas.

It borders Highway 30, going from Caguas to Humacao, and Rafael Cordero Ave. Kimco Realty Corp. owns the adjacent Plaza Centro II retail property which has Costco, Sam's Club and PetSmart among its tenants.

[16] On April 12, 2022, it was reported that BH Properties, a Los Angeles based real estate investment company, had acquired out of foreclosure Plaza Centro I, a 283,454 square foot strip shopping center.

[17] On May 2, 2024, it was reported that Ross Dress for Less would officially be opening at the Plaza Centro I shopping center portion, taking over the former space of the Kmart store which sat vacant since 2020.