[2] It received a remake with virtual reality support, Please, Don't Touch Anything 3D, that was co-developed with Escalation Studios and released on December 7, 2016 on Steam for Windows and Mac OS X.

[3] An enhanced port of Please, Don't Touch Anything was released for Nintendo Switch on November 22, 2018 with updated graphics and more solutions.

The player assumes control of the game's main character, who is locked in a mysterious room when their colleague goes for a bathroom break.

[4] The player must study the instructional poster in the room to figure out how to manipulate the panel, and different combinations of actions can unlock a large number of different endings.

[1][2] Tyler Wilde of PC Gamer called it an "enjoyable little puzzle box" but "not meaningful", saying that he wished its narrative were more "interesting", similar to games such as Papers, Please or The Stanley Parable.