Pleioptygma is a genus of large sea snails, marine gastropod mollusks in the superfamily Muricoidea.

In the genus Pleioptygma, the shell is medium to large in size.

[1] The type description of the genus Pleioptygma by Timothy Abbott Conrad (1863)[2] reads as follows: Subfusiform; aperture long; columella with very oblique plaits, numerous, alternated in size, or irregular, the largest being the second one from above.Although the shell of these gastropods looks similar to that of mitrids (family Mitridae), they are unrelated enough to require their own family.

The family Pleioptygmatidae has been defined based on the anatomy of the only extant species Pleioptygma helenae: The foot is relatively large in comparison to the size of the shell.

[1] Species within the genus Pleioptygma include: This article incorporate public domain text from the reference [2]