Plymptonville is a census-designated place (CDP) in Clearfield County, Pennsylvania, United States.

The West Branch Susquehanna River forms part of the border between Plymptonville and Clearfield.

U.S. Route 322 passes through the community, leading south into Clearfield and west 20 miles (32 km) to DuBois.

There were 495 housing units at an average density of 379.1 per square mile (146.4/km2).

31.5% of all households were made up of individuals, and 16.6% had someone living alone who was 65 years of age or older.