[3][4][5] The podcast debuted in January 2017 and airs three times per week, hosted by a rotating cast of former Barack Obama staffers Jon Favreau, Tommy Vietor, Jon Lovett, and Dan Pfeiffer.

[10] Four Pod Save America one-hour HBO TV specials aired in fall 2018 to cover the U.S. midterm elections.

[14] In an interview with Recode's Kara Swisher, the hosts have stated that, rather than continue the previous podcast, the election of Donald Trump as President of the United States spurred them to create a progressive media company with a network of podcasts.

[18] The podcast typically covers recent news items relating to politics, including the Trump administration, the US government and the Democratic Party, as well as center-left grassroots activism.

[10] The New York Times described the podcast as "one of the big breakout hits of the nascent resistance movement",[7] and "the left's answer to conservative talk radio... with a shoestring budget and no organizational backing, its hosts seem to have created something that liberals have spent almost two decades, and hundreds of millions of dollars, futilely searching for".