Poggio Renatico (Poggese: Al Puz; Ferrarese: Al Pògio) is a comune (municipality) in the Province of Ferrara in the Italian region Emilia-Romagna, located about 30 kilometres (19 mi) northeast of Bologna and about 12 kilometres (7 mi) southwest of Ferrara.

Poggio Renatico borders on the following municipalities: Baricella, Ferrara, Galliera, Malalbergo, Terre del Reno, Vigarano Mainarda.

During the Middle Ages, the region of Poggio Renatico was fortified by the rulers of Bologna through a discontinuous line of towers and castles that provided exclusive control of fishing and river trade and protection against the expansionist intentions of neighboring Ferrara.

Poggio Renatico was hit by the 2012 Emilia earthquakes which caused the Lambertini Castle clock tower to collapse.

The earthquake also damaged the dome and bell tower of the Abbey Church of St. Michael the Archangel.