[3] Point Loma is accredited by the Western Association of Schools and Colleges (WASC).

It was dedicated in 1925 as Point Loma Junior-Senior High school, serving grades 7 through 12.

The school holds the distinction of having produced two major-league baseball pitchers who threw perfect games - David Wells and Don Larsen.

Point Loma High School offers a large variety of Advanced Placement classes, ranging from Music Theory to Physics.

The school offers a variety of men's and women's competitive sports:[10] The Pointer football team won CIF championships four times, in 1966, 1982, 1987 and 1991, all during the tenure of football head coach Bennie Edens.

PLHS sailing teams also won the Mallory Trophy, the national fleet-racing championship, eight times (1993, 2003, 2004, 2005, 2012, 2014, 2017, and 2018), a record unmatched by any other school.

[16] In 2003 PLHS Sailor Parker Shinn won the Cressy Trophy, the national singlehanded championship of the ISSA.

[26][27] English teacher Larry Zeiger taught a class in musical theater called “Contemporary voices in literature” from 1977 until his retirement in 2007.

The students were all seniors, and “Zeiger’s show” became a beloved senior-year school tradition during the 31 years of its existence.

[28] The 2003 production "Sticky Fingers: A Tale of Saks, Lies and Videotape", which was inspired by the Winona Ryder shoplifting incident, received national attention.