Poix-de-Picardie (French pronunciation: [pwa də pikaʁdi], literally Poix of Picardy; Picard: Poé-d’Picardie) is a commune in the Somme department in Hauts-de-France in northern France.

The commune is situated at the junction of the N1 and N29 roads, some 20 miles (32 km) southwest of Amiens, at the bottom of a rather steep-sided valley, confined by Normandy to the south and Picardy to the north.

The commune has rail access at the Poix-de-Picardie station, on the Rouen to Amiens line.

The Tyrrel, or Tirel, family were Lords of Poix from the twelfth to the fifteenth century.

Walter's grandson Hugh Tyrrel, baron of Castleknock, played a prominent role in the Norman Conquest of Ireland and in the Third Crusade.